Tizanidine Impurity 68 HCl CAS 51322-80-6 (free base)
| CAS No. | 51322-80-6 (free base) |
| Molecular Formula | C7H3ClN4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tizanidine Impurity 68 HCl (CAS 51322-80-6 (free base), C7H3ClN4SHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tizanidine Impurity 68 HCl (C7H3ClN4SHCl) is characterized by a nitrile group, sulfur-containing functionality, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tizanidine Impurity 68 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3ClN4S HCl |
| Molecular Weight | 247.10 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Tizanidine Standards
- Tizanidine EP Impurity C (CAS 1147548-83-1)
- Tizanidine EP Impurity F (CAS 1147548-85-3)
- Tizanidine-d4 Hydrochloride (CAS 1188263-51-5)
- Tizanidine-D4 (CAS 1188331-19-2)
- Tizanidine Guanidine Impurity (CAS 125292-37-7)
- Tizanidine Impurity 44 (CAS 13907-88-5)
- Tizanidine RC 1 (CAS 1391053-77-2)
- Tizanidine Impurity 6 (CAS 173532-15-5)
Recommended Standards
- Teprenone impurity 46 (CAS CATO-C4X-208146)
- Azilsartan Impurity 127 (CAS CATO-C4X-1096127)
- Rasagiline Impurity 2 (CAS 1276516-51-8)
- 6-Hydroxy Warfarin (CAS 17834-02-5)
- 2-(5-Propylisoxazol-4-yl)acetic acid (CAS 155602-48-5)
- Di-tert-butyl 4,4'-((pyrimidine-4,6-diylbis(oxy))bis(methylene))bis(piperidine-1-carboxylate) (CAS 1353956-51-0)
- Scoparone (CAS 120-08-1)
- 2-Chloro-6-fluoro-3-formylphenylboronic acid (CAS 1451392-95-2)
- 4-(((5-Bromopyridin-2-yl)thio)methyl)-5-chloro-1,2,3-thiadiazole (CAS 1241418-85-8)
- Liraglutide Impurity 26 (CAS CATO-C4X-199226)
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